Triphenylphosphine → Phosphonium, (1,2-diethoxy-2-oxoethyl)triphenyl-, chloride (1:1)

HRID 445852

反応式

HRID 445852 の反応式
[CH2:1]([O:3][C:4](=[O:10])[CH:5]([Cl:9])[O:6][CH2:7][CH3:8])[CH3:2].[C:11]1([P:17]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C(Cl)(Cl)Cl>[Cl-:9].[CH2:7]([O:6][CH:5]([P+:17]([C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)[C:4]([O:3][CH2:1][CH3:2])=[O:10])[CH3:8]

参加物

4

反応物 2

HCID 11776TriphenylphosphineHCID 2724873Ethyl 2-chloro-2-ethoxyacetate

生成物 1

HCID 11327835Phosphonium, (1,2-diethoxy-2-oxoethyl)triphenyl-, chloride (1:1)収率 82%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

To a solution of 2-chloro-2-ethoxyacetic acid ethyl ester (10 g, 60 mmol) in chloroform (30 mL) was added triphenylphosphine (15.7 g, 60 mmol) and stirred overnight at room temperature. The solvent was removed in vacuo, and diethyl ether was added. The solvent was again removed and dried on high vacuum to give (1,2-diethoxy-2-oxoethyl)triphenylphosphonium chloride (21 g, 82% yield) (679) as a foamy solid.

後処理

  1. customThe solvent was removed in vacuo, and diethyl ether
  2. additionwas added
  3. customThe solvent was again removed
  4. customdried on high vacuum

出典と根拠

ORDレコード
ord-2b9a860869ac44618919f38e159b26dd
出典データセット
uspto-grants-2013_07
特許番号
US08476308B2

関連ノート

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