Butyl iodide → 3-Butyl-2,4,5-trimethylthiazol-3-ium iodide

HRID 448019ノート

反応式

HRID 448019 の反応式
[CH3:1][C:2]1[S:3][C:4]([CH3:8])=[C:5]([CH3:7])[N:6]=1.[CH2:9]([I:13])[CH2:10][CH2:11][CH3:12]>C(#N)C>[I-:13].[CH2:9]([N+:6]1[C:5]([CH3:7])=[C:4]([CH3:8])[S:3][C:2]=1[CH3:1])[CH2:10][CH2:11][CH3:12]

参加物

4

反応物 2

HCID 10962Butyl iodideHCID 616532,4,5-Trimethylthiazole

生成物 1

HCID 691655913-Butyl-2,4,5-trimethylthiazol-3-ium iodide

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A mixture of 2,4,5-trimethylthiazole (1.3 g, 10 mmol) and n-butyl iodide (7.4 g, 40 mmol) in anhydrous acetonitrile (30 mL) was refluxed for 72 hours and then concentrated under reduced pressure to provide the crude thiazolium salt. 1H NMR (300 MHz, DMSO-d6) δ 0.95 (t, J=7 Hz, 3H), 1.39 (sextet, J=7 Hz, 2H), 1.65 (m, 2H), 2.43 (s, 6H), 2.96 (s, 3H), 4.25 (m, 2H).

後処理

  1. temperaturewas refluxed for 72 hours
  2. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-20b9fb863e514c1190cbe561ccf3576c
出典データセット
uspto-grants-2013_07
特許番号
US08481574B2

反応ノート

読み込み中…