Sodium Hydroxide → HCID 59302986、化合物

HRID 448121ノート

反応式

HRID 448121 の反応式
C[O:2][C:3](=[O:32])[C:4]1[CH:9]=[CH:8][C:7]([NH:10][S:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([CH3:23])([CH3:22])[CH3:21])=[CH:16][CH:15]=2)(=[O:13])=[O:12])=[C:6]([C:24]2[N:28]([CH3:29])[C:27]([CH2:30][CH3:31])=[N:26][N:25]=2)[CH:5]=1.[OH-].[Na+]>C1COCC1>[C:20]([C:17]1[CH:18]=[CH:19][C:14]([S:11]([NH:10][C:7]2[CH:8]=[CH:9][C:4]([C:3]([OH:32])=[O:2])=[CH:5][C:6]=2[C:24]2[N:28]([CH3:29])[C:27]([CH2:30][CH3:31])=[N:26][N:25]=2)(=[O:12])=[O:13])=[CH:15][CH:16]=1)([CH3:23])([CH3:22])[CH3:21]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 59302970HCID 59302970、化合物

生成物 1

HCID 59302986HCID 59302986、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
60 °C

実験手順

A 10 mL scintillation vial was charged with 4-(4-tert-butyl-benzenesulfonylamino)-3-(5-ethyl-4-methyl-4H-[1,2,4]triazol-3-yl)-benzoic acid methyl ester (20 mg, 0.044 mmol) and 3 M NaOH (aq)/THF (1:3) (1.5 mL). The reaction was heated to 60° C. and stirred overnight. The following day, the volatiles were removed in vacuo to about 200 μL at which point the solution was purified by preparative TLC to afford 4-(4-tert-butyl-benzenesulfonylamino)-3-(5-ethyl-4-methyl-4H-[1,2,4]triazol-3-yl)-benzoic acid as a light yellow solid: MS (ES) M+H expect 443.2, found 443.4.

後処理

  1. customThe following day, the volatiles were removed in vacuo to about 200 μL at which point the solution
  2. customwas purified by preparative TLC

出典と根拠

ORDレコード
ord-9588595bf72c4067b05b8f446e49b462
出典データセット
uspto-grants-2013_07
特許番号
US08481579B2

反応ノート

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