Dimethylformamide → 4-Bromo-2,2-diphenylbutyric chloride

HRID 448809

反応式

HRID 448809 の反応式
[Br:1][CH2:2][CH2:3][C:4]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:5](O)=[O:6].S(Cl)([Cl:22])=O.CN(C=O)C>C(Cl)(Cl)Cl>[Br:1][CH2:2][CH2:3][C:4]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:5]([Cl:22])=[O:6]

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 24386Thionyl Chloride2 回HCID 27569594-Bromo-2,2-diphenylbutyric acid

生成物 1

HCID 222500664-Bromo-2,2-diphenylbutyric chloride

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

4-Bromo-2,2-diphenylbutyric acid (D) (Aldrich Chemical Company, Inc.) (23 g, 72 mmol) was suspended in chloroform (150 mL), and thionyl chloride (20 mL) was added dropwise. After addition of thionyl chloride, DMF (0.2 mL) was added, and the resulting solution was heated at reflux for 4 hours. The reaction mixture was then concentrated under reduced pressure to provide 4-bromo-2,2-diphenylbutyric acid chloride (E) as a pale yellow oil that was used for next step without further purification.

後処理

  1. additionwas added
  2. temperaturethe resulting solution was heated
  3. temperatureat reflux for 4 hours
  4. concentrationThe reaction mixture was then concentrated under reduced pressure

出典と根拠

ORDレコード
ord-220ebb96453644fca7e51a9f5a6e1e52
出典データセット
uspto-grants-2013_07
特許番号
US08481743B2

関連ノート

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