Hydroxyamine hydrochloride → (4-Dihydroxyboranyl-phenyl)-phenyl-methanone oxime
反応式
[C:1]([C:9]1[CH:14]=[CH:13][C:12]([B:15]([OH:17])[OH:16])=[CH:11][CH:10]=1)(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[NH2:19][OH:20]>N1C=CC=CC=1.CCO>[OH:16][B:15]([OH:17])[C:12]1[CH:13]=[CH:14][C:9]([C:1]([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[N:19][OH:20])=[CH:10][CH:11]=1参加物
5
実験手順
A solution of 4-benzoyl phenyl boronic acid (226.00 mg, 1.00 mmol) and hydroxylamine hydrochloride (84.00 mg, 1.20 mmol) in pyridine (5 mL) and EtOH (5 mL) was refluxed at 125° C. for 24 h. Reaction was then concentrated in vacuo to give a crude product which was used for next step without further purification. MS (ES+): m/z 241.89 (100)[MH+]. HPLC: tR=2.56 min (Open Lynx polar—5 min).
後処理
- customReaction
- concentrationwas then concentrated in vacuo
出典と根拠
- ORDレコード
- ord-ac4c869296e3422a9372d6a17a0fcc14
- 出典データセット
- uspto-grants-2013_07
- 特許番号
- US08481733B2
反応ノート
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