Oxalyl chloride → HCID 86621147、化合物

HRID 450028ノート

反応式

HRID 450028 の反応式
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[CH:7]=[C:8]2[N:13]([CH:14]=1)[CH:12]=[CH:11][CH:10]=[CH:9]2.[C:15](Cl)(=[O:19])[C:16]([Cl:18])=[O:17]>C1COCC1>[O:19]=[C:15]([C:14]1[N:13]2[C:8]([CH:9]=[CH:10][CH:11]=[CH:12]2)=[CH:7][C:6]=1[C:2]1[S:1][CH:5]=[CH:4][CH:3]=1)[C:16]([Cl:18])=[O:17]

参加物

4

反応物 2

HCID 65578Oxalyl chlorideHCID 8530432-(Thiophen-2-yl)indolizine

生成物 1

HCID 86621147HCID 86621147、化合物収率 41.3%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To an ice-cold solution of 2-thiophen-2-yl-indolizine (0.5 g, 2.51 mmol) in THF (8 ml) was added oxalyl chloride (0.3 ml, 3.48 mmol). The reaction mixture was stirred at room temperature for 30 min. The solvent was evaporated under vacuum. The crude product was recrystallized from dichloromethane-hexane to give oxo-(2-thiophen-2-yl-indolizin-3-yl)-acetyl chloride (0.3 g, 41%).

後処理

  1. customThe solvent was evaporated under vacuum
  2. customThe crude product was recrystallized from dichloromethane-hexane

出典と根拠

ORDレコード
ord-9b40d8e8cbf541d5b5b5a4a43c84107b
出典データセット
uspto-grants-2013_07
特許番号
US08486962B2

反応ノート

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