p-Aminoacetophenone → 4-Amino-alpha-methylbenzenemethanol

HRID 450038

反応式

HRID 450038 の反応式
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([NH2:10])=[CH:6][CH:5]=1)=[O:3].[BH4-].[Na+]>CO>[NH2:10][C:7]1[CH:8]=[CH:9][C:4]([CH:2]([OH:3])[CH3:1])=[CH:5][CH:6]=1

参加物

4

反応物 2

HCID 7468p-AminoacetophenoneHCID 4311764Sodium borohydride

生成物 1

HCID 857534-Amino-alpha-methylbenzenemethanol収率 80%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 4-amino acetophenone (0.5 g, 3.7 mmol) in methanol (10 ml), was added sodium borohydride (0.27 g, 7.4 mmol, 2 eq) at 0° C. The reaction mixture was stirred for 3 hr at room temperature. The solvent was evaporated and water was added. The compound was extracted with ethyl acetate, then the organic layer was dried over anhydrous sodium sulfate, filtered and concentrated to dryness to yield pure 1-(4-amino-phenyl)-ethanol (0.4 g, 80%).

後処理

  1. customThe solvent was evaporated
  2. additionwater was added
  3. extractionThe compound was extracted with ethyl acetate
  4. dry with materialthe organic layer was dried over anhydrous sodium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated to dryness

出典と根拠

ORDレコード
ord-cb06a862c1374d518862cadc08beb88f
出典データセット
uspto-grants-2013_07
特許番号
US08486962B2

関連ノート

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