Ammonium formate → 2-isopropoxypyridin-3-amine
反応式
[CH:1]([O:4][C:5]1[C:10]([N+:11]([O-])=O)=[CH:9][CH:8]=[CH:7][N:6]=1)([CH3:3])[CH3:2].C([O-])=O.[NH4+]>C(O)C.[OH-].[OH-].[Pd+2]>[CH:1]([O:4][C:5]1[C:10]([NH2:11])=[CH:9][CH:8]=[CH:7][N:6]=1)([CH3:3])[CH3:2]参加物
5
反応条件
- 温度
- 90 °C
実験手順
Palladium hydroxide on carbon (20%, 0.076 g, 0.54 mmol) was added into a solution of 2-iso-propoxy-3-nitro-pyridine (1.97 g, 10.8 mmol) and ammonium formate (3.40 g, 54.0 mmol) in ethanol (100 mL) at ambient temperature. The solution was stirred for 2 hours at 90° C., cooled to ambient temperature, filtered through Celite and washed with MeOH. The filtrate was concentrated in vacuo and triturated from diethyl ether to yield brown oil which was used in the next step without further purification.
後処理
- temperaturecooled to ambient temperature
- filtrationfiltered through Celite
- washwashed with MeOH
- concentrationThe filtrate was concentrated in vacuo
- customtriturated from diethyl ether
- customto yield brown oil which
- customwas used in the next step without further purification
出典と根拠
- ORDレコード
- ord-38b385b86d064a22905507dafa8eb245
- 出典データセット
- uspto-grants-2013_07
- 特許番号
- US08486953B2
反応ノート
読み込み中…