Bromine → HCID 67334263、化合物
反応式
[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([NH2:10])=[N:8][CH:9]=2)[CH2:3][CH2:2]1.[Br:11]Br.S([O-])([O-])(=O)=S.[Na+].[Na+]>C(Cl)(Cl)Cl>[Br:11][C:6]1[C:7]([NH2:10])=[N:8][CH:9]=[C:4]([CH:1]2[CH2:3][CH2:2]2)[CH:5]=1参加物
5
実験手順
To a solution of 5-cyclopropyl-pyridin-2-ylamine (1.1 g, 8.19 mmol) in dry chloroform (100 mL) was added bromine (0.42 mL, 8.2 mmol) in chloroform (11 mL) at room temperature and stirred for 18 hours. An aqueous solution of sodium thiosulfate was added, the aqueous phase was extracted with dichloromethane, the combined organic phases were dried over sodium sulfate, the solvent was evaporated and the residue purified by silica gel chromatography using ethyl acetate/hexane as eluent. The title compound was obtained as light yellow oil (1.0 g, 57%).
後処理
- extractionthe aqueous phase was extracted with dichloromethane
- dry with materialthe combined organic phases were dried over sodium sulfate
- customthe solvent was evaporated
- customthe residue purified by silica gel chromatography
出典と根拠
- ORDレコード
- ord-a89899d0bc4e43eaa31002532f897ecd
- 出典データセット
- uspto-grants-2013_07
- 特許番号
- US08486967B2
反応ノート
読み込み中…