L-Methionine → 3-(2,5-Dimethyl-pyrrol-1-yl)-5-isopropyl-1-methyl-1H-pyrazole

HRID 45152

反応式

HRID 45152 の反応式
[CH3:1][C:2]1[N:3]([C:8]2[CH:12]=[C:11]([CH:13]([CH3:15])[CH3:14])[NH:10][N:9]=2)[C:4]([CH3:7])=[CH:5][CH:6]=1.[H-].[Na+].N[C@H:19](C(O)=O)CCSC.[Cl-].[NH4+]>C1COCC1.C(Cl)Cl>[CH3:1][C:2]1[N:3]([C:8]2[N:9]([CH3:19])[N:10]=[C:11]([CH:13]([CH3:15])[CH3:14])[CH:12]=2)[C:4]([CH3:7])=[CH:5][CH:6]=1.[CH3:1][C:2]1[N:3]([C:8]2[CH:12]=[C:11]([CH:13]([CH3:15])[CH3:14])[N:10]([CH3:19])[N:9]=2)[C:4]([CH3:7])=[CH:5][CH:6]=1

参加物

8

反応物 4

HCID 6137L-MethionineHCID 24758Sodium hydrideHCID 25517Ammonium ChlorideHCID 593940413-(2,5-dimethyl-pyrrol-1-yl)-5-isopropyl-1H-pyrazole

生成物 2

HCID 674314505-(2,5-Dimethyl-pyrrol-1-yl)-3-isopropyl-1-methyl-1H-pyrazole収率 29%HCID 674331323-(2,5-Dimethyl-pyrrol-1-yl)-5-isopropyl-1-methyl-1H-pyrazole収率 63%

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 3-(2,5-dimethyl-pyrrol-1-yl)-5-isopropyl-1H-pyrazole (7.7 g, 37.9 mmol) in THF (400 mL) that is purged with nitrogen is added NaH (2.272 g, 56.8 mmol) at 0° C. The mixture is stirred for 10 min in the ice bath then for 10 min at room temperature. Met (4.74 mL, 76 mmol) is added and the mixture is stirred at room temperature for 1 h. At that point the reaction is diluted with DCM and treated with saturated solution of ammonium chloride (10 mL). The mixture is concentrated to dryness and the residue is partitioned in water and DCM. The organic layer is combined, dried over sodium sulfate, concentrated and absorbed onto silica to purify by FCC (0-30% EtOAC/Heptane) to give 5-(2,5-Dimethyl-pyrrol-1-yl)-3-isopropyl-1-methyl-1H-pyrazole (2.4 g, 29%) as the first peak and 3-(2,5-Dimethyl-pyrrol-1-yl)-5-isopropyl-1-methyl-1H-pyrazole (5.24 g, 63%) as the second peak. MS (ESI) m/z 218.3 (m+1).

後処理

  1. concentrationThe mixture is concentrated to dryness
  2. customthe residue is partitioned in water
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated
  5. customabsorbed onto silica
  6. customto purify by FCC (0-30% EtOAC/Heptane)

出典と根拠

ORDレコード
ord-d0b6d568edcc42c4baf54071ba01d9ce
出典データセット
uspto-grants-2013_09
特許番号
US08541432B2

関連ノート

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