5-Aminobenzimidazole → HCID 178450103、化合物

HRID 452062

反応式

HRID 452062 の反応式
FC(F)(F)C([O-])=O.[NH2:8][C:9]1[CH:17]=[CH:16][C:12]2[N:13]=[CH:14][NH:15][C:11]=2[CH:10]=1.[CH2:18]([O:22][C:23]1[CH:30]=[CH:29][C:26]([CH:27]=O)=[CH:25][CH:24]=1)[CH2:19][CH2:20][CH3:21].[Si](C#N)(C)(C)C.[N:37]1([C:42](N2C=CN=C2)=[O:43])C=CN=[CH:38]1>>[NH:13]1[C:12]2[CH:16]=[CH:17][C:9]([N:8]3[CH:27]([C:26]4[CH:29]=[CH:30][C:23]([O:22][CH2:18][CH2:19][CH2:20][CH3:21])=[CH:24][CH:25]=4)[CH2:38][NH:37][C:42]3=[O:43])=[CH:10][C:11]=2[N:15]=[CH:14]1

参加物

6

反応物 5

HCID 136235-AminobenzimidazoleHCID 682631,1'-CarbonyldiimidazoleHCID 798134-ButoxybenzaldehydeHCID 82115Trimethylsilyl cyanideHCID 84468Trifluoroacetate

生成物 1

HCID 178450103HCID 178450103、化合物

実験手順

The compound was synthesized as trifluoroacetate salt starting from 5-aminobenzimidazole (0.585 g, 4.4 mmol), 4-butoxybenzaldehyde (0.691 mL, 4 mmol), TMSCN (0.5 mL, 4 mmol), PdC (10%, 0.02 g), TEA (1.03 mL, 7.4 mmol), di-(imidazol-1-yl)methanone (0.658, 4.06 mmol) as described in method 2. The product was purified by means of preparative HPLC.

後処理

  1. customThe product was purified by means of preparative HPLC

出典と根拠

ORDレコード
ord-f64d2906073f478486ba152c0c86acf2
出典データセット
uspto-grants-2013_07
特許番号
US08486940B2

関連ノート

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