5-Aminobenzimidazole → HCID 51030962、化合物

HRID 452071

反応式

HRID 452071 の反応式
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]2[N:6]=[CH:7][NH:8][C:4]=2[CH:3]=1.[O:11]1[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][O:19][C:20]2[CH:27]=[CH:26][C:23]([CH:24]=O)=[CH:22][CH:21]=2)[CH2:13][CH2:12]1.[Si](C#N)(C)(C)C.[N:34]1([C:39](N2C=CN=C2)=[O:40])C=CN=[CH:35]1>>[O:11]1[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][O:19][C:20]2[CH:27]=[CH:26][C:23]([CH:24]3[N:1]([C:2]4[CH:10]=[CH:9][C:5]5[N:6]=[CH:7][NH:8][C:4]=5[CH:3]=4)[C:39](=[O:40])[NH:34][CH2:35]3)=[CH:22][CH:21]=2)[CH2:13][CH2:12]1

参加物

5

反応物 4

HCID 136235-AminobenzimidazoleHCID 682631,1'-CarbonyldiimidazoleHCID 82115Trimethylsilyl cyanideHCID 37199024-(2-Morpholinoethoxy)benzaldehyde

生成物 1

HCID 51030962HCID 51030962、化合物

実験手順

The compound was synthesized as ditrifluoroacetate salt starting from 5-aminobenzimidazole (0.585 g, 4.4 mmol), 4-(2-morpholinoethoxy)benzaldehyde (0.941 g, 4 mmol), TMSCN (0.5 mL, 4 mmol), PdC (10%, 0.02 g), TEA (1.34 mL, 9.6 mmol), di-(imidazol-1-yl)methanone (0.582 g, 3.6 mmol) as described in method 2. The product was purified by means of preparative HPLC.

後処理

  1. customThe product was purified by means of preparative HPLC

出典と根拠

ORDレコード
ord-a09b34d2006140fb960c4f057a2d045f
出典データセット
uspto-grants-2013_07
特許番号
US08486940B2

関連ノート

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