3-(2-Hydroxyethyl)-1-{4-nitro-2-[(1E)-prop-1-en-1-yl]phenyl}pyridin-2(1H)-one → 1-(4-Amino-2-propyl phenyl)-3-(2-hydroxyethyl)pyridin-2(1H)-one

HRID 452237ノート

反応式

HRID 452237 の反応式
[OH:1][CH2:2][CH2:3][C:4]1[C:5](=[O:22])[N:6]([C:10]2[CH:15]=[CH:14][C:13]([N+:16]([O-])=O)=[CH:12][C:11]=2/[CH:19]=[CH:20]/[CH3:21])[CH:7]=[CH:8][CH:9]=1.[H][H]>C1COCC1.[Pd]>[NH2:16][C:13]1[CH:14]=[CH:15][C:10]([N:6]2[CH:7]=[CH:8][CH:9]=[C:4]([CH2:3][CH2:2][OH:1])[C:5]2=[O:22])=[C:11]([CH2:19][CH2:20][CH3:21])[CH:12]=1

参加物

5

反応物 2

HCID 595366073-(2-Hydroxyethyl)-1-{4-nitro-2-[(1E)-prop-1-en-1-yl]phenyl}pyridin-2(1H)-oneHCID 178418361HCID 178418361、化合物

生成物 1

HCID 595366101-(4-Amino-2-propyl phenyl)-3-(2-hydroxyethyl)pyridin-2(1H)-one

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8028Tetrahydrofuran溶媒

実験手順

520 mg (1.73 mmol) of the compound from Example 46A are dissolved in 10 ml of THF. 30 mg of palladium on carbon are added, and the mixture is hydrogenated at RT in a hydrogen atmosphere under atmospheric pressure. The mixture is then filtered through kieselguhr, the filter cake is washed three times with THF and the filtrate is freed from the solvent. The reaction product is reacted further without further purification. This gives 471 mg (89% of theory) of the desired product.

後処理

  1. filtrationThe mixture is then filtered through kieselguhr
  2. washthe filter cake is washed three times with THF
  3. customThe reaction product is reacted further without further purification

出典と根拠

ORDレコード
ord-e4fe05ddb33f4d29a97eb634e14e236c
出典データセット
uspto-grants-2013_07
特許番号
US08487111B2

反応ノート

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