Methanol → N-[4-(hydrazinocarbonyl)-2-pyridyl]-3-phenylpropionamide

反応式

[C:1]1([CH2:7][CH2:8][C:9]([NH:11][C:12]2[CH:13]=[C:14]([CH:29]=[CH:30][N:31]=2)[C:15]([NH:17][NH:18]C(OCC2C=CC=CC=2)=O)=[O:16])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CO>[Pd].O1CCCC1>[NH:17]([C:15]([C:14]1[CH:29]=[CH:30][N:31]=[C:12]([NH:11][C:9](=[O:10])[CH2:8][CH2:7][C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH:13]=1)=[O:16])[NH2:18]

参加物

実験手順

A mixture of benzyl 2-[2-[(3-phenylpropanoyl)amino]isonicotinoyl]hydrazinecarboxylate (1.10 g, 2.63 mmol), 10% palladium on carbon (50 mg), methanol (20 mL) and tetrahydrofuran (20 mL) was stirred under a hydrogen atmosphere at room temperature 18 hr. The reaction mixture was filtered, and the filtrate was concentrated to give the title compound (748 mg, yield 100%) as colorless crystals.