Sodium Hydroxide → 2-Amino-4-methyl-thiazole-5-carboxylic acid
反応式
[NH2:1][C:2]1[S:3][C:4]([C:8]([O:10]CC)=[O:9])=[C:5]([CH3:7])[N:6]=1.[OH-].[Na+]>O1CCCC1.O>[NH2:1][C:2]1[S:3][C:4]([C:8]([OH:10])=[O:9])=[C:5]([CH3:7])[N:6]=1参加物
5
実験手順
A mixture of ethyl 2-amino-4-methylthiazole-5-carboxylate (6.58 g, 35.5 mmol) and NaOH (5.40 g, 135.00 mmol) in tetrahydrofuran (60 mL) and water (30 mL) was heated to reflux overnight. Tetrahydrofuran was removed by evaporation, and the residue was neutralized with 5% hydrochloric acid solution to pH 5˜6. The precipitate obtained was collected by filtration and dried to afford 2-amino-4-methylthiazole-5-carboxylic acid (5.20 g, 94%); 1H NMR (DMSO-d6, 300 MHz) δ 7.63 (s, 2H), 2.30 (s, 3H). MS (ES+) m/z 159.1 (M+1).
後処理
- temperaturewas heated
- temperatureto reflux overnight
- customTetrahydrofuran was removed by evaporation
- customThe precipitate obtained
- filtrationwas collected by filtration
- customdried
出典と根拠
- ORDレコード
- ord-80b00884331e40f7ae8f1fced1fd8601
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08541457B2
反応ノート
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