Ethyl 4-phenyl-1,3-thiazole-2-carboxylate → 4-Phenylthiazole-2-carboxylic acid

HRID 453299ノート

反応式

HRID 453299 の反応式
C([O:3][C:4]([C:6]1[S:7][CH:8]=[C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:10]=1)=[O:5])C>C1COCC1.[OH-].[Na+]>[C:11]1([C:9]2[N:10]=[C:6]([C:4]([OH:5])=[O:3])[S:7][CH:8]=2)[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

参加物

4

反応物 1

HCID 24730326Ethyl 4-phenyl-1,3-thiazole-2-carboxylate

生成物 1

HCID 38785394-Phenylthiazole-2-carboxylic acid

試薬・触媒・溶媒 2

HCID 8028Tetrahydrofuran溶媒HCID 14798Sodium Hydroxide溶媒

実験手順

Ethyl-4-phenylthiazole-2-carboxylate (300 mg) was stirred overnight in a mixture of THF (4 mL) and 1N aqueous NaOH (1 mL) for 18 hours. The THF was removed under reduced pressure and the aqueous solution was acidified with 4N HCl, extracted with CH2Cl2, dried over Na2SO4 and concentrate to obtain 4-phenylthiazole-2-carboxylic acid which was used as is in the next step.

後処理

  1. customThe THF was removed under reduced pressure
  2. extractionextracted with CH2Cl2
  3. dry with materialdried over Na2SO4
  4. concentrationconcentrate

出典と根拠

ORDレコード
ord-ebe37f5047ed465890e100c15a560b13
出典データセット
uspto-grants-2013_07
特許番号
US08492401B2

反応ノート

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