Triphenylphosphine → Tert-butyl 2-(2-(benzyloxy)-5-(2-(pyrrolidin-1-yl)ethoxy)benzamido)-4-phenylbenzoate

1-(2-Hydroxyethyl)pyrrolidine (0.016 mL), triphenylphosphine (0.038 g), and diisopropyl azodicarboxylate (0.029 mL) were added to a tetrahydrofuran (1.2 mL) solution of tert-butyl 2-(2-(benzyloxy)-5-hydroxybenzamido)-4-phenylbenzoate (0.060 g), followed by stirring at room temperature for 25 minutes. To the reaction mixture, 1-(2-hydroxyethyl)pyrrolidine (0.016 mL), triphenylphosphine (0.038 g), and diisopropyl azodicarboxylate (0.029 mL) were added, followed by stirring at room temperature for 20 minutes. To the reaction mixture, 1-(2-hydroxyethyl)pyrrolidine (0.016 mL), triphenylphosphine (0.038 g), and diisopropyl azodicarboxylate (0.029 mL) were added, followed by stirring at room temperature for 30 minutes. To the reaction mixture, 1-(2-hydroxyethyl)pyrrolidine (0.016 mL), triphenylphosphine (0.038 g), and diisopropyl azodicarboxylate (0.029 mL) were added, followed by stirring at room temperature for 1 hour. The solvent was evaporated under reduced pressure, and the obtained residue was purified by silica gel column chromatography [eluent: 80-0% hexane/ethyl acetate] to obtain 0.071 g of tert-butyl 2-(2-(benzyloxy)-5-(2-(pyrrolidin-1-yl)ethoxy)benzamido)-4-phenylbenzoate.

1. stirringby stirring at room temperature for 20 minutes
2. stirringby stirring at room temperature for 30 minutes
3. stirringby stirring at room temperature for 1 hour
4. customThe solvent was evaporated under reduced pressure
5. customthe obtained residue was purified by silica gel column chromatography [eluent: 80-0% hexane/ethyl acetate]

ORDレコード

ord-852726363910460985e4e90b0fe0e484

出典データセット

uspto-grants-2013_07

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08492582B2