Montelukast sodium → Montelukast

HRID 458222

反応式

HRID 458222 の反応式
[CH3:1][C:2]([OH:41])([C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:9]=1[CH2:10][CH2:11][C@@H:12]([S:32][CH2:33][C:34]1([CH2:37][C:38]([O-:40])=[O:39])[CH2:36][CH2:35]1)[C:13]1[CH:14]=[CH:15][CH:16]=[C:17](/[CH:19]=[CH:20]/[C:21]2[CH:22]=[CH:23][C:24]3[CH:25]=[CH:26][C:27]([Cl:31])=[CH:28][C:29]=3[N:30]=2)[CH:18]=1)[CH3:3].[Na+].ClC1C=C2C(C=CC(C=CC3C=C([C@@H](OS(C)(=O)=O)CCC4C=CC=CC=4C(OC4CCCCO4)(C)C)C=CC=3)=N2)=CC=1.C(SCC1(CC(OC)=O)CC1)(=O)C>NN.C(=O)([O-])[O-].[Cs+].[Cs+].C(#N)C.O1C=CC=CC1>[CH3:3][C:2]([OH:41])([C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:9]=1[CH2:10][CH2:11][C@@H:12]([S:32][CH2:33][C:34]1([CH2:37][C:38]([OH:40])=[O:39])[CH2:35][CH2:36]1)[C:13]1[CH:14]=[CH:15][CH:16]=[C:17](/[CH:19]=[CH:20]/[C:21]2[CH:22]=[CH:23][C:24]3[CH:25]=[CH:26][C:27]([Cl:31])=[CH:28][C:29]=3[N:30]=2)[CH:18]=1)[CH3:1]

参加物

8

反応物 3

HCID 23663996Montelukast sodiumHCID 53482060Methyl 1-((acetylthio)methyl)cyclopropaneacetateHCID 54063535HCID 54063535、化合物

生成物 1

HCID 5281040Montelukast

試薬・触媒・溶媒 4

HCID 6342Acetonitrile溶媒HCID 9321Hydrazine溶媒HCID 10796Cesium carbonate溶媒HCID 186148Pyran溶媒

実験手順

EP 480717 discloses a process for preparing montelukast sodium by reacting 2-(2-(2-(3(S)-(3-(2-(7-chloro-2-quinolinyl)-ethenyl)phenyl)-3-(methanesulfonyloxy)propyl)phenyl)-2-propoxy)tetra hydro pyran with Methyl 1-(acetylthiomethyl)cyclopropane acetate in presence of hydrazine, cesium carbonate in acetonitrile as solvent to get methyl ester of Montelukast in pyran protected form, which is further reacted with pyridinium p-toluene sulfonate, sodium hydroxide in a mixture of methanol and tetrahydrofuran as a solvent to afford Montelukast sodium of Formula (I).

出典と根拠

ORDレコード
ord-145bdb32b2424f22b2a88c4ad4ce5a7a
出典データセット
uspto-grants-2007_03
特許番号
US07189853B2

関連ノート

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