Water → Purine-2,6(1H,3H)-dione, 7-(2-bromobenzyl)-8-chloro-1,3-dimethyl-

HRID 458625

反応式

HRID 458625 の反応式
[Cl:1][C:2]1[NH:11][C:10]2[C:9](=[O:12])[N:7]([CH3:8])[C:6](=[O:13])[N:5]([CH3:14])[C:4]=2[N:3]=1.[Br:15][C:16]1[CH:23]=[CH:22][CH:21]=[CH:20][C:17]=1[CH2:18]Br.CCOC(C)=O.O>CN(C=O)C.CCN(C(C)C)C(C)C>[Br:15][C:16]1[CH:23]=[CH:22][CH:21]=[CH:20][C:17]=1[CH2:18][N:11]1[C:10]2[C:9](=[O:12])[N:7]([CH3:8])[C:6](=[O:13])[N:5]([CH3:14])[C:4]=2[N:3]=[C:2]1[Cl:1]

参加物

7

反応物 4

HCID 962WaterHCID 8857Ethyl AcetateHCID 106618-ChlorotheophyllineHCID 769652-Bromobenzyl bromide

生成物 1

HCID 598207Purine-2,6(1H,3H)-dione, 7-(2-bromobenzyl)-8-chloro-1,3-dimethyl-

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒HCID 81531Diisopropylethylamine溶媒

反応条件

温度
65 °C

実験手順

8-Chlorotheophylline (10 g, 46.6 mmol) was dissolved in 250 ml of DMF and 8 ml of DIEA, and 2-bromobenzyl bromide (12.2 g, 48.9 mmol) was added. The mixture was stirred at 65° C. for 2 hours. The reaction mixture was added 20 ml of EtOAc and 250 ml of cold water. The white precipitate was collected by filtration to afford compound (10A) as white crystals.

後処理

  1. filtrationThe white precipitate was collected by filtration

出典と根拠

ORDレコード
ord-e6f9c7aad5964e9089d97203461a5454
出典データセット
uspto-grants-2007_03
特許番号
US07192952B2

関連ノート

読み込み中…