Tetrahydrofuran → HCID 22637025、化合物

HRID 459841

反応式

HRID 459841 の反応式
Br[C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[C:4](Cl)[CH:3]=1.C([Li])CCC.CCCCCC.[B:22]([O:27]C)([O:25]C)[O:23]C.C1C[O:32][CH2:31]C1>>[CH3:31][O:32][C:4]1[CH:3]=[C:2]([O:27][B:22]([OH:23])[OH:25])[CH:7]=[CH:6][C:5]=1[O:8][CH3:9]

参加物

5

反応物 4

HCID 8028TetrahydrofuranHCID 8470Trimethyl borateHCID 30165374-Bromo-2-chloroanisoleHCID 178418244HCID 178418244、化合物

生成物 1

HCID 22637025HCID 22637025、化合物

実験手順

To a THF solution of 4-bromo-2-chloroanisole was added an n-butyllithium/n-hexane solution at −78° C., followed by 30 minutes of stirring. Then, trimethyl borate was added and the whole was warmed to room temperature, followed by 30 minutes of stirring. Using the residue obtained by evaporation of the solvent instead of 3,4-dimethoxyphenylboric acid, an objective compound was obtained in a similar manner to Reference Example 1.

後処理

  1. waitfollowed by 30 minutes
  2. stirringof stirring

出典と根拠

ORDレコード
ord-1115ae46fc4c4112a137d8b25c599060
出典データセット
uspto-grants-2007_03
特許番号
US07196080B2

関連ノート

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