Diphenyl carbonate → N-[2-Methyl-3-[3-(1-piperidinylmethyl)phenoxy]propyl]hydrazine carboxamide

HRID 4604

反応式

HRID 4604 の反応式
[CH3:1][CH:2]([CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([CH2:13][N:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[CH:8]=1)[CH2:3][NH2:4].C1(O[C:27](=[O:35])OC2C=CC=CC=2)C=CC=CC=1.O.[NH2:37][NH2:38]>C(O)C>[CH3:1][CH:2]([CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([CH2:13][N:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[CH:8]=1)[CH2:3][NH:4][C:27]([NH:37][NH2:38])=[O:35]

参加物

5

反応物 3

HCID 7597Diphenyl carbonateHCID 24654Hydrazine hydrate (1:1)HCID 137906092-Methyl-3-[3-(1-piperidinylmethyl)phenoxy]-1-propanamine

生成物 1

HCID 13657331N-[2-Methyl-3-[3-(1-piperidinylmethyl)phenoxy]propyl]hydrazine carboxamide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

2.2 g (8 mmol) of 2-methyl-3-[3-(1-piperidinylmethyl)phenoxy]-1-propanamine in 20 ml of ethanol are stirred together with 1.9 g (8 mmol) of diphenylcarbonate at room temperature for 12 hours. 4 g of hydrazine hydrate is then added to the solution and the reaction mixture is heated under reflux for one hour. Isolation of the product is carried out as described in Example 1.

後処理

  1. temperaturethe reaction mixture is heated
  2. temperatureunder reflux for one hour

出典と根拠

ORDレコード
ord-1a0aab0702614837a64963489ec21c3d
出典データセット
uspto-grants-1988_02
特許番号
US04727081

関連ノート

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