Hydrochloric Acid → HCID 22759262、化合物

HRID 460837ノート

反応式

HRID 460837 の反応式
[BH4-].[Na+].[C:3]([CH:6]([CH2:16][CH2:17][CH2:18][CH:19]([OH:29])[CH2:20][O:21][C:22]1[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=1)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14])(=[O:5])[CH3:4].[OH-].[Na+].Cl>CCOCC.O>[OH:5][CH:3]([CH:6]([CH2:16][CH2:17][CH2:18][CH:19]([OH:29])[CH2:20][O:21][C:22]1[CH:23]=[CH:24][C:25]([F:28])=[CH:26][CH:27]=1)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14])[CH3:4]

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 4311764Sodium borohydrideHCID 22759241HCID 22759241、化合物

生成物 1

HCID 22759262HCID 22759262、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 3283Diethyl Ether溶媒

実験手順

Sodium borohydride (1.2 g., 0.03 mole) is added to a solution of 8-acetyl-12-hydroxy-13-(4-fluorophenoxy)-tridecanoic acid (15.4 g., 0.04 mole) and sodium hydroxide (2.0 g., 0.05 mole) in 70 ml. of water. The resulting solution is allowed to stand at room temperature for 19 hours, and is then acidified to Congo Red with concentrated hydrochloric acid. The oily product is taken up in ether, washed with water and dried over sodium sulfate. The ether is evaporated leaving 12.8 g. of the crude title compound as a brown oil.

後処理

  1. washwashed with water
  2. dry with materialdried over sodium sulfate
  3. customThe ether is evaporated
  4. customleaving 12.8 g

出典と根拠

ORDレコード
ord-00980e8d16634a08afe712a6dabbf3e4
出典データセット
uspto-grants-1977_12
特許番号
US04061643

反応ノート

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