Ethyl Bromide → HCID 22759318、化合物

HRID 460847ノート

反応式

HRID 460847 の反応式
[Mg].BrCC.[CH2:5]([O:8][CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][O:10]1)[C:6]#[CH:7].[F:15][C:16]1[CH:25]=[CH:24][C:19]([O:20][CH2:21][CH:22]=[O:23])=[CH:18][CH:17]=1.[Cl-].[NH4+]>O1CCCC1.O>[O:10]1[CH2:11][CH2:12][CH2:13][CH2:14][CH:9]1[O:8][CH2:5][C:6]#[C:7][CH:22]([OH:23])[CH2:21][O:20][C:19]1[CH:24]=[CH:25][C:16]([F:15])=[CH:17][CH:18]=1

参加物

8

反応物 5

HCID 6332Ethyl BromideHCID 25517Ammonium ChlorideHCID 98609Tetrahydro-2-(2-propynyloxy)-2H-pyranHCID 5462224MagnesiumHCID 110518692-(4-Fluorophenoxy)acetaldehyde

生成物 1

HCID 22759318HCID 22759318、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒2 回

実験手順

To the Grignard reagent prepared from magnesium (12.2 g., 0.5 mole) and bromoethane (54.5 g., 0.5 mole) in tetrahydrofuran (400 ml.) is added, dropwise, during 30 minutes, a solution of tetrahydro-2-(2-propynyloxy)-2H-pyran (67.3 g., 0.5 mole) in tetrahydrofuran (50 ml.). The mixture is stirred at room temperature for 1 hour and then treated, dropwise, during 1 hour with 4-fluorophenoxy-acetaldehyde (61.6 g., 0.4 mole). The resulting mixture is heated at reflux for 1 hour, then cooled and poured into an ice cold saturated solution of ammonium chloride in water.

後処理

  1. additionis added
  2. additiontreated
  3. temperatureThe resulting mixture is heated
  4. temperatureat reflux for 1 hour
  5. temperaturecooled

出典と根拠

ORDレコード
ord-7c743f7eab3a4edb90280485f0b1b5f1
出典データセット
uspto-grants-1977_12
特許番号
US04061643

反応ノート

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