N,N'-Diethylthiourea → 3-Ethyl-2-ethylimino-4-(4-methyl-3-sulfamoylphenyl)-1,3-thiazolidine-4-ol-hydrochloride

HRID 461156

反応式

HRID 461156 の反応式
[Cl:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([CH3:11])=[C:7]([S:12](=[O:15])(=[O:14])[NH2:13])[CH:6]=1)=[O:4].[CH2:16]([NH:18][C:19]([NH:21][CH2:22][CH3:23])=[S:20])[CH3:17]>C(OC(C)C)(C)C>[ClH:1].[CH2:22]([N:21]1[C:3]([C:5]2[CH:10]=[CH:9][C:8]([CH3:11])=[C:7]([S:12](=[O:15])(=[O:14])[NH2:13])[CH:6]=2)([OH:4])[CH2:2][S:20][C:19]1=[N:18][CH2:16][CH3:17])[CH3:23]

参加物

4

反応物 2

HCID 2735009N,N'-DiethylthioureaHCID 136287832-Chloro-4'-methyl-3'-sulfamoylacetophenone

生成物 1

HCID 227604333-Ethyl-2-ethylimino-4-(4-methyl-3-sulfamoylphenyl)-1,3-thiazolidine-4-ol-hydrochloride

試薬・触媒・溶媒 1

HCID 7914Diisopropyl Ether溶媒

実験手順

5 g of 2-chloro-4'-methyl-3'-sulfamoylacetophenone and 2.7 g of 1,3-diethylthiourea were reacted as prescribed in Example 12. After addition of 200 ml of diisopropyl ether the solvent was decanted and the oily end product was crystallized under ethyl acetate heated to 40° to 50° C. Colorless solid body, melting point: 160° C (decomposition).

後処理

  1. customwas decanted
  2. customthe oily end product was crystallized under ethyl acetate
  3. temperatureheated to 40° to 50° C

出典と根拠

ORDレコード
ord-31fcc2290c774320bcc607a62f00ec11
出典データセット
uspto-grants-1977_12
特許番号
US04061761

関連ノート

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