2-Hydroxyacetamide → 2-(4-Chloro-2-methylphenoxymethyl)-4-oxazolidinone

HRID 461284

反応式

HRID 461284 の反応式
[Cl:1][C:2]1[CH:11]=[CH:10][C:5]([O:6][CH2:7][CH:8]=[O:9])=[C:4]([CH3:12])[CH:3]=1.[C:13]([NH2:17])(=[O:16])[CH2:14]O>O1CCCC1.CCOCC>[Cl:1][C:2]1[CH:11]=[CH:10][C:5]([O:6][CH2:7][CH:8]2[NH:17][C:13](=[O:16])[CH2:14][O:9]2)=[C:4]([CH3:12])[CH:3]=1

参加物

5

反応物 2

HCID 690212-HydroxyacetamideHCID 123914592-(4-Chloro-2-methylphenoxy)acetaldehyde

生成物 1

HCID 123914922-(4-Chloro-2-methylphenoxymethyl)-4-oxazolidinone収率 18.2%

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

A solution containing 4.6 g (0.025 mole) of (4-chloro-2-methylphenoxy)acetaldehyde and 2.1 g (0.028 mole) of glycolamide in 25 ml of tetrahydrofuran and 25 ml of ether was allowed to stand at ambient temperature for 24 hours. The resulting product was washed with 5% sodium carbonate and water, dried and purified by silica chromatography to give 1.1 g of 2-(4-chloro-2-methylphenoxymethyl)-4-oxazolidinone as a white crystalline solid melting at 109°-112°.

後処理

  1. washThe resulting product was washed with 5% sodium carbonate and water
  2. customdried
  3. custompurified by silica chromatography

出典と根拠

ORDレコード
ord-bd0886031fb84779b40d854807ed63a2
出典データセット
uspto-grants-1977_12
特許番号
US04062670

関連ノート

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