Triethylamine → 1-Methoxy-3-(1,2,3,4-tetrahydro-1-naphthyl)-thiourea

HRID 461384

反応式

HRID 461384 の反応式
Cl.[CH3:2][O:3][NH2:4].C(N(CC)CC)C.[CH:12]1([N:22]=[C:23]=[S:24])[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH2:15][CH2:14][CH2:13]1>C(Cl)Cl>[CH3:2][O:3][NH:4][C:23]([NH:22][CH:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH2:15][CH2:14][CH2:13]1)=[S:24]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 521874O-Methylhydroxylamine hydrochlorideHCID 213934781-Isothiocyanato-1,2,3,4-tetrahydronaphthalene

生成物 1

HCID 213934961-Methoxy-3-(1,2,3,4-tetrahydro-1-naphthyl)-thiourea

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

To an ice-cold, stirred mixture of 0.02 mole of methoxyamine hydrochloride and methylene chloride is added 0.02 mole of triethylamine. The mixture is then allowed to warm to about 15° to 25° C. while a solution of 0.01 mole of 1,2,3,4-tetrahydro-1-naphthyl isothiocyanate in methylene chloride is added dropwise. The mixture is stirred overnight at room temperature and then filtered. The filtrate is washed with water, dried (sodium sulfate), and the solvent evaporated at reduced pressure to give the title compound.

後処理

  1. additionis added dropwise
  2. filtrationfiltered
  3. washThe filtrate is washed with water
  4. dry with materialdried (sodium sulfate)
  5. customthe solvent evaporated at reduced pressure

出典と根拠

ORDレコード
ord-593bab6047ca4353aad3d69cf57c8233
出典データセット
uspto-grants-1977_12
特許番号
US04062856

関連ノート

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