4-Nitrobenzoyl chloride → 2'-[2-(1-Methyl-2-piperidyl)ethyl]-4-nitrobenzanilide

HRID 461899

反応式

HRID 461899 の反応式
[N+:1]([C:4]1[CH:12]=[CH:11][C:7]([C:8](Cl)=[O:9])=[CH:6][CH:5]=1)([O-:3])=[O:2].[NH2:13][C:14]1[CH:28]=[CH:27][CH:26]=[CH:25][C:15]=1[CH2:16][CH2:17][CH:18]1[CH2:23][CH2:22][CH2:21][CH2:20][N:19]1[CH3:24]>N1C=CC=CC=1>[CH3:24][N:19]1[CH2:20][CH2:21][CH2:22][CH2:23][CH:18]1[CH2:17][CH2:16][C:15]1[CH:25]=[CH:26][CH:27]=[CH:28][C:14]=1[NH:13][C:8](=[O:9])[C:7]1[CH:11]=[CH:12][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=1

参加物

4

反応物 2

HCID 85024-Nitrobenzoyl chlorideHCID 110852822-(2-Aminophenethyl)-1-methylpiperidine

生成物 1

HCID 205600862'-[2-(1-Methyl-2-piperidyl)ethyl]-4-nitrobenzanilide

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

Reaction of 4-nitrobenzoyl chloride (6.5 g., 0.035 mole) and 2-(o-aminophenethyl)-1-methylpiperidine (6.0 g., 0.0275 mole) in 35 ml. of pyridine according to the method of Example 25 provides 2'-[2-(1-methyl-2-piperidyl)ethyl]-4-nitrobenzanilide. Crystallization from ethyl acetate provides analytically pure material, m.p. 162°-163.5° C.

出典と根拠

ORDレコード
ord-acce8eb540c44055b2e302906f248ea9
出典データセット
uspto-grants-1977_12
特許番号
US04064254

関連ノート

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