(4-Aminophenoxy)benzene → 1-(4-Phenoxyphenyl)piperazine

HRID 462007

反応式

HRID 462007 の反応式
Br[CH2:2][CH2:3][NH:4][CH2:5][CH2:6]Br.[O:8]([C:15]1[CH:21]=[CH:20][C:18]([NH2:19])=[CH:17][CH:16]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.C([O-])([O-])=O.[Na+].[Na+]>CO>[O:8]([C:15]1[CH:16]=[CH:17][C:18]([N:19]2[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]2)=[CH:20][CH:21]=1)[C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

参加物

5

反応物 3

HCID 8764(4-Aminophenoxy)benzeneHCID 10340Sodium CarbonateHCID 415719Bis(2-bromoethyl)amine

生成物 1

HCID 30173561-(4-Phenoxyphenyl)piperazine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 62.4 parts of bis-(β-bromoethyl)amine dihybromide in 160 parts of methanol there were added 37 parts of para-phenoxyaniline. The mixture was refluxed for 10 hours. 10.6 parts of Na2CO3 were then added and the reaction mixture was refluxed for a further 10 hours. After cooling, the precipitate was filtered off, washed with 80 parts of methanol and dried.

後処理

  1. temperatureThe mixture was refluxed for 10 hours
  2. temperaturethe reaction mixture was refluxed for a further 10 hours
  3. temperatureAfter cooling
  4. filtrationthe precipitate was filtered off
  5. washwashed with 80 parts of methanol
  6. customdried

出典と根拠

ORDレコード
ord-2368a7cc6aa643bf82c15e20288aef90
出典データセット
uspto-grants-1977_12
特許番号
US04064245

関連ノート

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