Formaldehyde → Oxotremorine 1
反応式
[CH3:1][N:2]([CH2:6][C:7]#[CH:8])[C:3](=[O:5])[CH3:4].[CH2:9]=O.[NH:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1>O1CCOCC1>[CH3:1][N:2]([CH2:6][C:7]#[C:8][CH2:9][N:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1)[C:3](=[O:5])[CH3:4]参加物
5
実験手順
Under a nitrogen atmosphere, a solution containing 13.0 g. (0.12 mole) of N-methyl-N-propargylacetamide, 5.8 g. of paraformaldehyde, 10.5 g. (0.15 mole) of pyrrolidine and a trace of cuprous chloride in 80 ml. of dioxane was refluxed for 5 hrs. and allowed to stand overnight. The mixture was filtered remaining oil was distilled and redistilled giving N-methyl-N-(4-pyrrolidino-2-butynyl)acetamide, boiling at 120° C. at 0.03 mm.
後処理
- additionUnder a nitrogen atmosphere, a solution containing 13.0 g
- filtrationThe mixture was filtered
- distillationwas distilled
- distillationredistilled
出典と根拠
- ORDレコード
- ord-ed98a0d44b504502b844f3326f398ecc
- 出典データセット
- uspto-grants-1977_12
- 特許番号
- US04065471
反応ノート
読み込み中…