Water → 5-Bromo-2,4-dichlorobenzoic acid

HRID 46225

反応式

HRID 46225 の反応式
[Cl:1][C:2]1[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[Br:12]Br.O>ClS(O)(=O)=O.[S]>[Br:12][C:8]1[C:9]([Cl:11])=[CH:10][C:2]([Cl:1])=[C:3]([CH:7]=1)[C:4]([OH:6])=[O:5]

参加物

6

反応物 3

HCID 962WaterHCID 57872,4-Dichlorobenzoic Acid2 回HCID 24408Bromine

生成物 1

HCID 218625655-Bromo-2,4-dichlorobenzoic acid収率 187.5%

試薬・触媒・溶媒 2

HCID 5362487Sulfur触媒HCID 24638Chlorosulfonic acid溶媒

反応条件

温度
70 °C

実験手順

To a solution of 2,4-dichlorobenzoic acid (compound 80, 25.0 g, 131 mmol) in chlorosulfonic acid (100 mL) was added bromine (3.4 mL, 65 mmol) and sulfur (0.20 g, 6.6 mmol). The reaction mixture was stirred at 70° C. overnight and then cooled to ambient temperature. The reaction mixture was poured into iced water. The resulting solid was isolated by filtration and dried in vacuo to yield title compound (32.9 g, 93%) as pale brown solid.

後処理

  1. temperaturecooled to ambient temperature
  2. customThe resulting solid was isolated by filtration
  3. customdried in vacuo

出典と根拠

ORDレコード
ord-541340427c5d4696b208240ea8e76d24
出典データセット
uspto-grants-2013_09
特許番号
US08541380B2

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