Water → 5-Bromo-2,4-dichlorobenzoic acid
反応式
[Cl:1][C:2]1[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[Br:12]Br.O>ClS(O)(=O)=O.[S]>[Br:12][C:8]1[C:9]([Cl:11])=[CH:10][C:2]([Cl:1])=[C:3]([CH:7]=1)[C:4]([OH:6])=[O:5]参加物
6
反応条件
- 温度
- 70 °C
実験手順
To a solution of 2,4-dichlorobenzoic acid (compound 80, 25.0 g, 131 mmol) in chlorosulfonic acid (100 mL) was added bromine (3.4 mL, 65 mmol) and sulfur (0.20 g, 6.6 mmol). The reaction mixture was stirred at 70° C. overnight and then cooled to ambient temperature. The reaction mixture was poured into iced water. The resulting solid was isolated by filtration and dried in vacuo to yield title compound (32.9 g, 93%) as pale brown solid.
後処理
- temperaturecooled to ambient temperature
- customThe resulting solid was isolated by filtration
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-541340427c5d4696b208240ea8e76d24
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08541380B2
反応ノート
読み込み中…