Benzyl Alcohol → Benzyl phenylacetate

HRID 462306

反応式

HRID 462306 の反応式
[C:1]1([CH2:7][C:8]([OH:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:11](O)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C1(C)C=CC(S(O)(=O)=O)=CC=1.C1(C)C=CC=CC=1>O>[C:1]1([CH2:7][C:8]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

6

反応物 4

HCID 244Benzyl AlcoholHCID 999Phenylacetic AcidHCID 1140TolueneHCID 6101p-Toluenesulfonic acid

生成物 1

HCID 60999Benzyl phenylacetate収率 83%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of phenyl acetic acid (27.2 g.), benzyl alcohol (21.6 g.) and p-toluenesulfonic acid (380 mg.) in 100 ml. of toluene was heated under reflux under a Dean-Stark trap until the theoretical (3.6 ml.) quantity of water had been collected. On cooling, the solution was washed with dilute NaHCO3 and saturated NaCl and solvent was removed in vacuo.. The resulting oil was distilled at 125°-129° (0.4 torr)1 to give pure benzyl phenylacetate, 37.7 g. (83% yield). ##STR230##

後処理

  1. customhad been collected
  2. temperatureOn cooling
  3. washthe solution was washed with dilute NaHCO3 and saturated NaCl and solvent
  4. customwas removed in vacuo
  5. distillationThe resulting oil was distilled at 125°-129° (0.4 torr)1

出典と根拠

ORDレコード
ord-b6015e5e9c4f4828894d6a1ff668db79
出典データセット
uspto-grants-1977_12
特許番号
US04065623

関連ノート

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