Acetoacetanilide → Isoquinoline

HRID 462488

反応式

HRID 462488 の反応式
CC(CC(N[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=O)=O.[C:14](#[N:18])[CH2:15][C:16]#N>>[CH:14]1[C:15]2[C:8](=[CH:9][CH:10]=[CH:11][CH:16]=2)[CH:13]=[CH:12][N:18]=1

参加物

3

反応物 2

HCID 7592AcetoacetanilideHCID 8010Malononitrile

生成物 1

HCID 8405Isoquinoline収率 85%

実験手順

The procedure of Reference Example 5 was repeated except that 0.04 mole of acetoacetic anilide (Reference Example 8) or 0.04 mole of malononitrile (Reference Example 9) was employed instead of acetylacetone to give a corresponding isoquinoline derivative with yield of 85%, 65%, respectively. The structures of the obtained isoquinoline derivatives were identified by means of elementary analysis, IR spectrum and 1H-NMR spectrum.

出典と根拠

ORDレコード
ord-72762389c1184c49931862144a7299b7
出典データセット
uspto-grants-1985_05
特許番号
US04515915

関連ノート

読み込み中…