Hydrogen Cyanide → 2-(2-Fluoro-4-trifluoromethylphenylamino)-3-methylbutyronitrile
反応式
ClC1C=[C:4](C(F)(F)F)[CH:5]=[CH:6][C:7]=1[NH2:8].[F:13][C:14]1[CH:15]=[C:16]([C:21]([F:24])([F:23])[F:22])[CH:17]=[CH:18][C:19]=1[NH2:20].C#N.[CH:27](=O)C(C)C>O>[F:13][C:14]1[CH:15]=[C:16]([C:21]([F:22])([F:23])[F:24])[CH:17]=[CH:18][C:19]=1[NH:20][CH:6]([CH:5]([CH3:27])[CH3:4])[C:7]#[N:8]参加物
6
実験手順
Following the procedure of Example 1, each of 3-chloro-4-aminobenzotrifluoride and 3-fluoro-4-aminobenzotrifluoride is reacted with hydrogen cyanide and isobutyraldehyde, in a neat, initially water-free system, to give the respective nitrile, 2-(2-chloro-4-trifluoro-methylphenylamino)-3-methylbutyronitrile and 2-(2-fluoro-4-trifluoromethylphenylamino)-3-methylbutyronitrile.
出典と根拠
- ORDレコード
- ord-f4fb8e7036e843d7865338e8ca199b44
- 出典データセット
- uspto-grants-1985_05
- 特許番号
- US04517130
反応ノート
読み込み中…