1,2-Ethanedione, 1,2-bis(4-chlorophenyl)- → 4,5-Bis-(4-chlorophenyl)-5-hydroxy-2-thioxo-3-pyrroline-3-carbonitrile

HRID 462688

反応式

HRID 462688 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)=O)=[O:9])=[CH:4][CH:3]=1.[C:19]([CH2:21][C:22]([NH2:24])=[S:23])#[N:20]>N1CCCCC1.C(Cl)(Cl)Cl>[Cl:18][C:15]1[CH:16]=[CH:17][C:12]([C:10]2[C:8]([C:5]3[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=3)([OH:9])[NH:24][C:22](=[S:23])[C:21]=2[C:19]#[N:20])=[CH:13][CH:14]=1

参加物

5

反応物 2

HCID 189461,2-Ethanedione, 1,2-bis(4-chlorophenyl)-HCID 14162772-Cyanoethanethioamide

生成物 1

HCID 132362254,5-Bis-(4-chlorophenyl)-5-hydroxy-2-thioxo-3-pyrroline-3-carbonitrile

試薬・触媒・溶媒 2

HCID 8082Piperidine触媒HCID 6212Chloroform溶媒

実験手順

A suspension of 22.3 g. 4,4'-dichlorobenzil, 6.5 g. 2-cyanothioacetamide, 20 drops of piperidine and 200 ml. chloroform is stirred for 20 hours at ambient temperature. The yellow precipitate obtained is filtered off with suction, well washed with chloroform and dried. There are obtained 22.0 g. of the desired compound in the form of yellow crystals; m.p. 213° C. (decomp.).

後処理

  1. additionA suspension of 22.3 g
  2. customThe yellow precipitate obtained
  3. filtrationis filtered off with suction
  4. washwell washed with chloroform
  5. customdried
  6. customThere are obtained 22.0 g

出典と根拠

ORDレコード
ord-8d02aad0da4c4edcb6cbbdcdbe59e98d
出典データセット
uspto-grants-1985_05
特許番号
US04517185

関連ノート

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