[CH2:1]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([C:15]1[CH:20]=[CH:19][C:18]([NH2:21])=[CH:17][CH:16]=1)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C([SiH](CC)CC)C.FC(F)(F)C(O)=O.[OH-].[Na+]>O>[CH2:1]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:15]1[CH:20]=[CH:19][C:18]([NH2:21])=[CH:17][CH:16]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1To a mixture of 16 g of formula (VIII) compound obtained in the preceding example and 21 g of triethylsilane were added 30.1 ml of trifluoroacetic acid and it was left under agitation for 20 hours at room temperature. Then, it was diluted with water, basified by means of concentrated NaOH, extracted with methylene chloride, washed with water, dried on sodium sulfate, the filtrate was evaporated and the residue chromatographed on a silica column [eluent: methylene chloride (99)-methanol (1) mixture]. Thus, 14 g of the expected compound were obtained in the form of an oil (Yield: 92%).
読み込み中…
