Pyridine → 2,4-difluoro-N-(thiazol-2-yl)benzenesulfonamide

HRID 46290

反応式

HRID 46290 の反応式
[NH2:1][C:2]1[S:3][CH:4]=[CH:5][N:6]=1.N1C=CC=CC=1.[F:13][C:14]1[CH:19]=[C:18]([F:20])[CH:17]=[CH:16][C:15]=1[S:21](Cl)(=[O:23])=[O:22]>C(Cl)Cl>[F:13][C:14]1[CH:19]=[C:18]([F:20])[CH:17]=[CH:16][C:15]=1[S:21]([NH:1][C:2]1[S:3][CH:4]=[CH:5][N:6]=1)(=[O:23])=[O:22]

参加物

5

反応物 3

HCID 1049PyridineHCID 21552-AminothiazoleHCID 27342732,4-Difluorobenzenesulfonyl Chloride

生成物 1

HCID 250389042,4-difluoro-N-(thiazol-2-yl)benzenesulfonamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

To a slurry of 2-aminothiazole (15.08 g, 0.1506 mol) in methylene chloride (100 mL) and pyridine (24 mL, 0.30 mol) was added dropwise over 20 minutes a solution of 2,4-difluorobenzenesulfonyl chloride (10 mL, 0.07 mol) in 10 mL of methylene chloride. After stirring at room temperature for 48 hours the reaction was concentrated and purified by flash column chromatography eluting with hexane/ethyl acetate. LCMS Rt=1.21 minutes MS m/z 277 [MH]+

後処理

  1. concentrationwas concentrated
  2. custompurified by flash column chromatography
  3. washeluting with hexane/ethyl acetate

出典と根拠

ORDレコード
ord-b083043d358544dcbd3734bbd645a5dc
出典データセット
uspto-grants-2013_09
特許番号
US08541588B2

関連ノート

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