Pyridine → 2,4-difluoro-N-(thiazol-2-yl)benzenesulfonamide
反応式
[NH2:1][C:2]1[S:3][CH:4]=[CH:5][N:6]=1.N1C=CC=CC=1.[F:13][C:14]1[CH:19]=[C:18]([F:20])[CH:17]=[CH:16][C:15]=1[S:21](Cl)(=[O:23])=[O:22]>C(Cl)Cl>[F:13][C:14]1[CH:19]=[C:18]([F:20])[CH:17]=[CH:16][C:15]=1[S:21]([NH:1][C:2]1[S:3][CH:4]=[CH:5][N:6]=1)(=[O:23])=[O:22]参加物
5
実験手順
To a slurry of 2-aminothiazole (15.08 g, 0.1506 mol) in methylene chloride (100 mL) and pyridine (24 mL, 0.30 mol) was added dropwise over 20 minutes a solution of 2,4-difluorobenzenesulfonyl chloride (10 mL, 0.07 mol) in 10 mL of methylene chloride. After stirring at room temperature for 48 hours the reaction was concentrated and purified by flash column chromatography eluting with hexane/ethyl acetate. LCMS Rt=1.21 minutes MS m/z 277 [MH]+
後処理
- concentrationwas concentrated
- custompurified by flash column chromatography
- washeluting with hexane/ethyl acetate
出典と根拠
- ORDレコード
- ord-b083043d358544dcbd3734bbd645a5dc
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08541588B2
反応ノート
読み込み中…