Potassium Hydroxide → 1-Chloro-4-(3-phenylpropyl)benzene

HRID 463513

反応式

HRID 463513 の反応式
[C:1]1([CH2:7][CH2:8][C:9]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=2)=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O.NN.[OH-].[K+]>C(O)COCCO>[Cl:17][C:14]1[CH:13]=[CH:12][C:11]([CH2:9][CH2:8][CH2:7][C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[CH:16][CH:15]=1

参加物

5

反応物 3

HCID 14797Potassium HydroxideHCID 24654Hydrazine hydrate (1:1)HCID 2473444'-Chloro-3-phenylpropiophenone

生成物 1

HCID 133008571-Chloro-4-(3-phenylpropyl)benzene

試薬・触媒・溶媒 1

HCID 8117Diethylene Glycol溶媒

実験手順

p-chlorophenyl phenylethyl ketone (25 g) was refluxed with hydrazine hydrate (13 g) and potassium hydroxide (18 g) in Digol (diethylene glycol) for one hour. The mixture was then distilled until the solution temperature in the still reached 175°. The mixture was then refluxed for 3 hours, cooled, poured into water and extracted with petroleum ether (Bpt 40°-60°). Evaporation of the extracts gave 1-(4-chlorophenyl)-3-phenylpropane Bbt. 110°/10-3 mm.

後処理

  1. distillationThe mixture was then distilled until the solution temperature in the still reached 175°
  2. temperatureThe mixture was then refluxed for 3 hours
  3. temperaturecooled
  4. additionpoured into water
  5. extractionextracted with petroleum ether (Bpt 40°-60°)
  6. customEvaporation of the extracts

出典と根拠

ORDレコード
ord-3ea19a854acc474080cbdd3124680918
出典データセット
uspto-grants-1985_05
特許番号
US04520007

関連ノート

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