Ammonium Chloride → 4-(2-Chloro-4-trifluoromethylphenoxy)-2-aminoaniline

HRID 463600

反応式

HRID 463600 の反応式
[Cl:1][C:2]1[CH:20]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:18]=[CH:17][C:3]=1[O:4][C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-])=O)=[C:7]([N+:14]([O-])=O)[CH:6]=1.[Cl-].[NH4+]>C(O)C.O.[Fe]>[Cl:1][C:2]1[CH:20]=[C:19]([C:21]([F:22])([F:24])[F:23])[CH:18]=[CH:17][C:3]=1[O:4][C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[C:7]([NH2:14])[CH:6]=1

参加物

5

反応物 2

HCID 25517Ammonium ChlorideHCID 156238Benzene, 2-chloro-1-(3,4-dinitrophenoxy)-4-(trifluoromethyl)-

生成物 1

HCID 135039484-(2-Chloro-4-trifluoromethylphenoxy)-2-aminoaniline

試薬・触媒・溶媒 2

HCID 23925Iron触媒HCID 19096565Water ethanol溶媒

実験手順

A mixture of 4-(2-chloro-4-trifluoromethylphenoxy)-1,2-dinitrobenzene (2.1 g, 5.8 mmol) and ammonium chloride (6.2 g, 116.0 mmol) is heated in ethanol/water (40 ml/20 ml) to 70°. Iron powder (3.2 g, 58.0 mmol) is added in small portions over 15 minutes, and the mixture is then heated under reflux for 2 hours. The reaction is filtered through celite and stripped. The residue is taken up in ether, washed with water, dried and stripped to give 4-(2-chloro-4-trifluoromethylphenoxy)-2-aminoaniline.

後処理

  1. temperaturethe mixture is then heated
  2. temperatureunder reflux for 2 hours
  3. filtrationThe reaction is filtered through celite
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-5de599c9e66a450487b437f2c6acaf5e
出典データセット
uspto-grants-1985_10
特許番号
US04544400

関連ノート

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