Pyridine → 4-(Methylsulfonamido)benzoic acid

HRID 463671

反応式

HRID 463671 の反応式
N1C=CC=CC=1.[NH2:7][C:8]1[CH:18]=[CH:17][C:11]([C:12]([O:14]CC)=[O:13])=[CH:10][CH:9]=1.[CH3:19][S:20](Cl)(=[O:22])=[O:21]>ClCCl>[CH3:19][S:20]([NH:7][C:8]1[CH:18]=[CH:17][C:11]([C:12]([OH:14])=[O:13])=[CH:10][CH:9]=1)(=[O:22])=[O:21]

参加物

5

反応物 3

HCID 1049PyridineHCID 2337BenzocaineHCID 31297Methanesulfonyl chloride

生成物 1

HCID 2506534-(Methylsulfonamido)benzoic acid

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

反応条件

温度
0 °C

実験手順

To 215.2 g (2.72 mole) of pyridine in 1250 ml of dichloromethane is added 238 g (1.44 mole) of ethyl 4-aminobenzoate. After cooling to 0° C., a solution of 177.6 g (1.55 mole) of methanesulfonyl chloride in 250 ml of dichloromethane is added with stirring. Upon completion of the addition, the ice bath is removed and the reaction is stirred for one hour at room temperature.

後処理

  1. additionUpon completion of the addition
  2. customthe ice bath is removed
  3. stirringthe reaction is stirred for one hour at room temperature

出典と根拠

ORDレコード
ord-98f76ec3828f43fabcd0c535838e6578
出典データセット
uspto-grants-1985_10
特許番号
US04544654

関連ノート

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