Isopropylamine → HCID 13458391、化合物

HRID 464019

反応式

HRID 464019 の反応式
[C:1]([NH:4][C:5]1[CH:14]=[CH:13][C:8]([C:9](=[O:12])[CH2:10]Cl)=[CH:7][CH:6]=1)(=[O:3])[CH3:2].O1CCOCC1.[CH:21]([NH2:24])([CH3:23])[CH3:22]>O>[C:1]([NH:4][C:5]1[CH:14]=[CH:13][C:8]([C:9](=[O:12])[CH2:10][NH:24][CH:21]([CH3:23])[CH3:22])=[CH:7][CH:6]=1)(=[O:3])[CH3:2]

参加物

5

反応物 3

HCID 6363IsopropylamineHCID 88054'-Chloroacetyl(acetanilide)HCID 312751,4-Dioxane

生成物 1

HCID 13458391HCID 13458391、化合物収率 89.6%

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

In a reactor, 21 g (0.1 mol) of 4-acetylaminophenacyl chloride are introduced into a mixture comprising 100 ml of dioxane, 26 ml (0.3 mol) of isopropylamine and 20 ml of water. The reaction medium is stirred at 30°-40° C. for 2 hours. After the addition of 500 ml of iced water, a precipitate is collected, washed and dried. Recrystallization from ethyl acetate gives 21 g of N-(4-acetylaminophenacyl)isopropylamine, which is in the form of a white powder. Melting point (inst.)=156° C.

後処理

  1. customa precipitate is collected
  2. washwashed
  3. customdried
  4. customRecrystallization from ethyl acetate

出典と根拠

ORDレコード
ord-4808f652adcb49a78b550fd4286098fc
出典データセット
uspto-grants-1985_10
特許番号
US04545996

関連ノート

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