Water → [6-(Hydroxymethyl)pyridin-3-yl]methanol

HRID 464079

反応式

HRID 464079 の反応式
C([O:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][O:13]C(=O)C)=[CH:8][N:7]=1)(=O)C.[H-].[Al+3].[Li+].[H-].[H-].[H-].O.[H-]>O1CCCC1>[OH:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][OH:13])=[CH:8][N:7]=1

参加物

6

反応物 4

HCID 962WaterHCID 166653HydrideHCID 202639862,5-Di(acetoxymethyl)pyridineHCID 21226445Aluminium lithium hydride

生成物 1

HCID 820251[6-(Hydroxymethyl)pyridin-3-yl]methanol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

2,5-Di(acetoxymethyl)pyridine (0.05 mole) is reduced with lithium aluminum hydride (0.025 mole) in tetrahydrofuran (50 ml.) at 0° C. with stirring. After one hour, water is added to decompose excess hydride, and the mixture is concentrated to dryness. The residue is extracted with hot isopropanol (2×60 ml.) and the extract is concentrated to dryness to give 2,5-di(hydroxymethyl) pyridine.

後処理

  1. concentrationthe mixture is concentrated to dryness
  2. extractionThe residue is extracted with hot isopropanol (2×60 ml.)
  3. concentrationthe extract is concentrated to dryness

出典と根拠

ORDレコード
ord-6c5e1a5b524b4b2f99b7ec93b2f076ea
出典データセット
uspto-grants-1985_10
特許番号
US04546106

関連ノート

読み込み中…