Acetic Acid → 3-Bromo-4-propylbenzoic acid

HRID 46415

反応式

HRID 46415 の反応式
C(O)(=O)C.[N+]([O-])(O)=O.[CH2:9]([C:12]1[CH:20]=[CH:19][C:15]([C:16]([OH:18])=[O:17])=[CH:14][CH:13]=1)[CH2:10][CH3:11].[Br:21]Br>O.[N+]([O-])([O-])=O.[Ag+]>[CH2:9]([C:12]1[CH:20]=[CH:19][C:15]([C:16]([OH:18])=[O:17])=[CH:14][C:13]=1[Br:21])[CH2:10][CH3:11]

参加物

7

反応物 4

HCID 176Acetic AcidHCID 944Nitric AcidHCID 24408BromineHCID 1376014-Propylbenzoic acid

生成物 1

HCID 203870433-Bromo-4-propylbenzoic acid

試薬・触媒・溶媒 2

HCID 24470Silver Nitrate触媒HCID 962Water溶媒2 回

実験手順

To a mixture of 150 ml of glacial acetic acid, 33 ml of concentrated nitric acid and 25 ml of water, were added 8.2 g (0.05 moles) of parapropyl benzoic acid and 8.8 g (0.055 moles) of bromine. Then, at a temperature of 25° C., and over a period of half an hour, a solution of 8.5 g (0.05 moles) of silver nitrate in 25 cc of water was added. The solution was stirred for three hours, thirty minutes following which the suspended solid was removed by filtration and rinsed until neutral. Thereafter, the acid was dissolved in ethanol. Recrystallization from hexane yielded 4-propyl-3-bromo-benzoic acid.

後処理

  1. waitThen, at a temperature of 25° C., and over a period of half an hour
  2. customwas removed by filtration
  3. washrinsed until neutral
  4. dissolutionThereafter, the acid was dissolved in ethanol
  5. customRecrystallization from hexane

出典と根拠

ORDレコード
ord-3a1733dc96d447078fc35cabe36a2cb0
出典データセット
uspto-grants-1979_11
特許番号
US04173545

関連ノート

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