Hydrochloric Acid → 3-Chloro-5-nitro-2(1H)-pyridinone

HRID 464624

反応式

HRID 464624 の反応式
[N+:1]([C:4]1[CH:5]=[CH:6][C:7](=[O:10])[NH:8][CH:9]=1)([O-:3])=[O:2].Cl.[Cl:12]([O-])(=O)=O.[K+]>O>[Cl:12][C:6]1[C:7](=[O:10])[NH:8][CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 794535-Nitropyridin-2-olHCID 6426889Potassium Chlorate

生成物 1

HCID 3362893-Chloro-5-nitro-2(1H)-pyridinone

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

5-Nitro-2-pyridone (Aldrich Chemical Company) (100 g, 0.71 mol) was added to 1 liter conc. HCl at room temperature, followed by the dropwise addition of a solution of potassium chlorate (87.5 g, 0.71 mol) in 1.2 liter water. A solid material formed during the addition. The mixture was stirred overnight, filtered, and the collected material recrystallized from 50 percent aqueous ethanol. The yield was 77.2 g, 62 percent, m.p. 196°-198° C.

後処理

  1. customA solid material formed during the addition
  2. filtrationfiltered
  3. customthe collected material recrystallized from 50 percent aqueous ethanol

出典と根拠

ORDレコード
ord-14f5395969a04bf0b5ae561b9969b5b2
出典データセット
uspto-grants-1985_10
特許番号
US04548888

関連ノート

読み込み中…