Dimethyl Sulfoxide → 5-Nitro-2-(2,2,2-trifluoroethoxy)pyridine

HRID 46465ノート

反応式

HRID 46465 の反応式
Cl[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][N:3]=1.[F:11][C:12]([F:16])([F:15])[CH2:13][OH:14].[OH-].[Li+].CS(C)=O>O>[F:11][C:12]([F:16])([F:15])[CH2:13][O:14][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][N:3]=1

参加物

6

反応物 4

HCID 679Dimethyl SulfoxideHCID 3939Lithium HydroxideHCID 64092,2,2-TrifluoroethanolHCID 783082-Chloro-5-nitropyridine

生成物 1

HCID 6137185-Nitro-2-(2,2,2-trifluoroethoxy)pyridine

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

2-Chloro-5-nitropyridine (9.5 grams), 2,2,2-trifluoroethanol (6.0 grams), and lithium hydroxide (4.0 grams) were mixed in 50 ml. of DMSO and stirred overnight (about 18 hours) at room temperature. The reaction mixture was then poured into water and the product was separated by filtration. It was crystallized from ethyl acetate-hexanes, yield 5.0 grams, m.p., 35°-37° C.

後処理

  1. customthe product was separated by filtration
  2. customIt was crystallized from ethyl acetate-hexanes, yield 5.0 grams
  3. custom35°-37° C.

出典と根拠

ORDレコード
ord-558bb867ab5c4bd4a3b4e2b03e7cc939
出典データセット
uspto-grants-1979_11
特許番号
US04173639

反応ノート

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