tert-Butanol → N-boc-4-chlorobenzenesulfonamide

HRID 465621

反応式

HRID 465621 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]=[C:12]=[O:13])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[C:14]([OH:18])([CH3:17])([CH3:16])[CH3:15]>>[C:14]([O:18][C:12]([NH:11][S:8]([C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=1)(=[O:9])=[O:10])=[O:13])([CH3:17])([CH3:16])[CH3:15]

参加物

3

反応物 2

HCID 6386tert-ButanolHCID 1385874-Chlorobenzenesulfonyl isocyanate

生成物 1

HCID 14796817N-boc-4-chlorobenzenesulfonamide

実験手順

The commercially available p-chlorophenylsulfonyl isocyanate (15.0 g, 58.6 mmol) is added dropwise to t-butanol (90 ml) and the mixture is allowed to stir at room temperature for 60 hours. The solvent is evaporated and the white solid is recrystallized from hexane and ethylacetate to obtain N-t-butoxycarbonyl-p-chlorophenylsulfonamide, m.p. 98°-99° C.

後処理

  1. customThe solvent is evaporated
  2. customthe white solid is recrystallized from hexane and ethylacetate

出典と根拠

ORDレコード
ord-c6fefe3fbe4c4b8ba246ce545c3a9649
出典データセット
uspto-grants-1992_10
特許番号
US05153214

関連ノート

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