Hydrochloric Acid → Sorbitol stearate

HRID 46602

反応式

HRID 46602 の反応式
[C:1](Cl)(=[O:19])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].[OH:21][CH2:22][C@@H:23]([C@H:25]([C@@H:27]([C@@H:29]([CH2:31][OH:32])[OH:30])[OH:28])[OH:26])[OH:24].Cl>C1(C)C=CC=CC=1.N1C=CC=CC=1>[C:1]([OH:19])(=[O:21])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].[OH:32][CH2:31][C@@H:29]([C@H:27]([C@@H:25]([C@@H:23]([CH2:22][OH:21])[OH:24])[OH:26])[OH:28])[OH:30]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 5780SorbitolHCID 8212Stearoyl chloride

生成物 1

HCID 86736698Sorbitol stearate

試薬・触媒・溶媒 2

HCID 1049Pyridine溶媒HCID 1140Toluene溶媒

反応条件

温度
90 °C

実験手順

411.5 g (1.358 mols) stearic acid chloride are dissolved in 3 l toluene and heated to 90° C. 41.23 g (0.22 mols) of sorbitol, dissolved in 200 ml pyridine are added dropwise to this mixture over 25 minutes. The solution is boiled (at approx. 110° C.) for 1 hour under reflux. After cooling, dilute hydrochloric acid is added to acidify the mixture, which is then washed with water until neutral and dried with dehydrated sodium sulphate. After concentration of the organic phase the sorbitol stearate crystallizes. It is recrystallized from methanol.

後処理

  1. additionare added dropwise to this mixture over 25 minutes
  2. custom(at approx. 110° C.)
  3. customfor 1 hour
  4. temperatureunder reflux
  5. temperatureAfter cooling
  6. washis then washed with water until neutral and
  7. dry with materialdried with dehydrated sodium sulphate
  8. customAfter concentration of the organic phase the sorbitol stearate crystallizes
  9. customIt is recrystallized from methanol

出典と根拠

ORDレコード
ord-d1dca84c9b584950b7b5fa1a15b7b248
出典データセット
uspto-grants-1979_11
特許番号
US04174325

関連ノート

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