Triphenylphosphine dibromide → HCID 14971319、化合物

HRID 466173ノート

反応式

HRID 466173 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[O:11][CH2:10][C:9]([CH2:12]O)=[CH:8][C:7]=2[CH:14]=1.[Br:15]P(Br)(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>C(#N)C>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[O:11][CH2:10][C:9]([CH2:12][Br:15])=[CH:8][C:7]=2[CH:14]=1

参加物

4

反応物 2

HCID 70579Triphenylphosphine dibromideHCID 13601222HCID 13601222、化合物

生成物 1

HCID 14971319HCID 14971319、化合物

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

6-Methoxy-3-(hydroxymethyl)-2H-1-benzopyran (4.35 g, 22.6 mmol) is dissolved in 70 ml of dry acetonitrile and treated with dibromotriphenylphosphorane (9.56 g, 22.6 mmol). After 15 min, the mixture is evaporated in vacuo. The residue is triturated with 100 ml of an ether/hexane mixture (1:1). The solid is removed by filtration (medium frit) and washed with several 50 ml portions of the ether/hexane mixture. The organic extracts are combined and evaporated to give 6-methoxy-3-(bromomethyl)-2H-1-benzopyran which is used without any further purification.

後処理

  1. customthe mixture is evaporated in vacuo
  2. customThe residue is triturated with 100 ml of an ether/hexane mixture (1:1)
  3. customThe solid is removed by filtration (medium frit)
  4. washwashed with several 50 ml portions of the ether/hexane mixture
  5. customevaporated

出典と根拠

ORDレコード
ord-d98e93658c5549a4a6365e494319f82a
出典データセット
uspto-grants-1992_10
特許番号
US05155130

反応ノート

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