Formaldehyde → HCID 15065517、化合物

HRID 466752ノート

反応式

HRID 466752 の反応式
[CH3:1][N:2]1[CH:6]=[CH:5][N:4]([CH2:7][C:8]#[CH:9])[C:3]1=[O:10].[CH2:11]=O.[NH:13]1[CH2:17][CH2:16][CH2:15][CH2:14]1>O1CCOCC1>[CH3:1][N:2]1[CH:6]=[CH:5][N:4]([CH2:7][C:8]#[C:9][CH2:11][N:13]2[CH2:17][CH2:16][CH2:15][CH2:14]2)[C:3]1=[O:10]

参加物

5

反応物 3

HCID 712FormaldehydeHCID 31268PyrrolidineHCID 150655051,3-Dihydro-1-methyl-3-(2-propyn-1-yl)-2H-imidazol-2-one

生成物 1

HCID 15065517HCID 15065517、化合物

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

The intermediate imidazolidinones and imidazolones were converted to the final products using the general procedures outlined in Scheme 2. 1,3-dihydro-1-methyl-3-(2-propynyl)-2H-imidazol-2-one was reacted with paraformaldehyde and pyrrolidine in dioxane using cuprous chloride as catalyst to give 1,3-dihydro-1-methyl-3-[4-(1-pyrrolidinyl)-2-butynyl]-2H-imidazol-2-one. The diethylamine analogue was prepared similarly and was reacted with cyanogen bromide to give the bromide XI which was reacted with imidazole to give 1,3-dihydro-1-[4-(1H-imidazol-1-yl)-2-butynyl]-3-methyl -2H-imidazol-2-one and with 1-acetyl-4-methylimidazole to give XII which was hydrolyzed to 1,3-dihydro-1-methyl-3-[4-(5-methyl-1H-imidazol-1-yl)-2-butynyl]-2H-imidazol-2-one. The imidazolidinone analogues of Table 1, imidazolones of Table 2 and immidazolidinedione and tetrahydropyrimidinones of Table 3 were prepared by these general procedures.

出典と根拠

ORDレコード
ord-2335ca88811f40acb78462dfee6cda1c
出典データセット
uspto-grants-1992_10
特許番号
US05157124

反応ノート

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