(4-Amino-3-nitrophenyl)methanol → (3,4-Diaminophenyl)methanol

HRID 46700

反応式

HRID 46700 の反応式
[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][OH:7])=[CH:4][C:3]=1[N+:10]([O-])=O.[H][H]>[Ni].O1CCCC1>[NH2:10][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:2]=1[NH2:1])[CH2:6][OH:7]

参加物

5

反応物 2

HCID 12902831(4-Amino-3-nitrophenyl)methanolHCID 178418361HCID 178418361、化合物

生成物 1

HCID 12902832(3,4-Diaminophenyl)methanol収率 82%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 8028Tetrahydrofuran溶媒

実験手順

Six grams (0.035 mole) of 4-amino-3-nitrobenzyl alcohol, 95 ml. of tetrahydrofuran and 0.5 g. of Raney Nickel were hydrogenated at 40 psi at room temperature until 3 moles of hydrogen were absorbed. The catalyst was filtered and the filtrate was evaporated in vacuo to yield 4.83 g. (82 percent yield) of 3,4-diaminobenzyl alcohol, mp. 74°-75° C.

後処理

  1. customwere absorbed
  2. filtrationThe catalyst was filtered
  3. customthe filtrate was evaporated in vacuo
  4. customto yield 4.83 g

出典と根拠

ORDレコード
ord-38b1408d5185446da164fb486c4e7a6f
出典データセット
uspto-grants-1979_11
特許番号
US04174454

関連ノート

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