2-Amino-4-Nitrophenol → 2-(Chloromethyl)-5-nitro-1,3-benzoxazole

HRID 467086

反応式

HRID 467086 の反応式
[NH2:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[OH:11].Cl.[Cl:13][CH2:14][C:15](=N)OCC>C(O)C>[Cl:13][CH2:14][C:15]1[O:11][C:3]2[CH:4]=[CH:5][C:6]([N+:8]([O-:10])=[O:9])=[CH:7][C:2]=2[N:1]=1

参加物

4

反応物 2

HCID 36133892-Amino-4-NitrophenolHCID 12470659Ethyl 2-chloroethanecarboximidate hydrochloride

生成物 1

HCID 27641892-(Chloromethyl)-5-nitro-1,3-benzoxazole

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

2-Amino-4-nitrophenol (10 g, 65 mmole) and ethyl chloroacetimidate hydrochloride (15.4 g, 97.5 mmole) were heated at reflux temperature in ethanol (100 ml) for 18 hours. The solvent was then removed by evaporation in vacuo and the residue recrystallised from ethanol to give the title compound, yield 9.0 g, m.p. 216°-217°.

後処理

  1. customThe solvent was then removed by evaporation in vacuo
  2. customthe residue recrystallised from ethanol

出典と根拠

ORDレコード
ord-0c7cdef324e84958856a1348304f2bf5
出典データセット
uspto-grants-1992_10
特許番号
US05158964

関連ノート

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